diff --git a/jenkins_jobs/cache.py b/jenkins_jobs/cache.py
index ee293d468..dfcb9998b 100644
--- a/jenkins_jobs/cache.py
+++ b/jenkins_jobs/cache.py
@@ -21,8 +21,11 @@ import logging
 import os
 import re
 import tempfile
+
+import fasteners
 import yaml
 
+from jenkins_jobs import errors
 
 logger = logging.getLogger(__name__)
 
@@ -43,6 +46,13 @@ class JobCache(object):
         host_vary = re.sub('[^A-Za-z0-9\-\~]', '_', jenkins_url)
         self.cachefilename = os.path.join(
             cache_dir, 'cache-host-jobs-' + host_vary + '.yml')
+
+        # generate named lockfile if none exists, and lock it
+        self._locked = self._lock()
+        if not self._locked:
+            raise errors.JenkinsJobsException(
+                "Unable to lock cache for '%s'" % jenkins_url)
+
         if flush or not os.path.isfile(self.cachefilename):
             self.data = {}
         else:
@@ -50,6 +60,18 @@ class JobCache(object):
                 self.data = yaml.load(yfile)
         logger.debug("Using cache: '{0}'".format(self.cachefilename))
 
+    def _lock(self):
+        self._fastener = fasteners.InterProcessLock("%s.lock" %
+                                                    self.cachefilename)
+
+        return self._fastener.acquire(delay=1, max_delay=2, timeout=60)
+
+    def _unlock(self):
+        if getattr(self, '_locked', False):
+            if getattr(self, '_fastener', None) is not None:
+                self._fastener.release()
+            self._locked = None
+
     @staticmethod
     def get_cache_dir():
         home = os.path.expanduser('~')
@@ -115,3 +137,4 @@ class JobCache(object):
             except Exception as e:
                 self._logger.error("Failed to write to cache file '%s' on "
                                    "exit: %s" % (self.cachefilename, e))
+        self._unlock()
diff --git a/requirements.txt b/requirements.txt
index 4f19904e8..07e73a21f 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -6,3 +6,4 @@ PyYAML>=3.10.0 # MIT
 pbr>=1.8 # Apache-2.0
 stevedore>=1.17.1 # Apache-2.0
 python-jenkins>=0.4.8
+fasteners
diff --git a/tests/cachestorage/test_cachestorage.py b/tests/cachestorage/test_cachestorage.py
index 8a9f533d7..138f14067 100644
--- a/tests/cachestorage/test_cachestorage.py
+++ b/tests/cachestorage/test_cachestorage.py
@@ -31,7 +31,8 @@ class TestCaseJobCache(base.BaseTestCase):
 
         with mock.patch('jenkins_jobs.builder.JobCache.save') as save_mock:
             with mock.patch('os.path.isfile', return_value=False):
-                jenkins_jobs.builder.JobCache("dummy")
+                with mock.patch('jenkins_jobs.builder.JobCache._lock'):
+                    jenkins_jobs.builder.JobCache("dummy")
             save_mock.assert_called_with()
 
     @mock.patch('jenkins_jobs.builder.JobCache.get_cache_dir',
@@ -43,4 +44,5 @@ class TestCaseJobCache(base.BaseTestCase):
         test_file = os.path.abspath(__file__)
         with mock.patch('os.path.join', return_value=test_file):
             with mock.patch('yaml.load'):
-                jenkins_jobs.builder.JobCache("dummy").data = None
+                with mock.patch('jenkins_jobs.builder.JobCache._lock'):
+                    jenkins_jobs.builder.JobCache("dummy").data = None