diff --git a/releasenotes/notes/Bump-dnspython-requirement-to-2.2.1-a3d062a1e16cc8a9.yaml b/releasenotes/notes/Bump-dnspython-requirement-to-2.2.1-a3d062a1e16cc8a9.yaml
new file mode 100644
index 000000000..e0e323a71
--- /dev/null
+++ b/releasenotes/notes/Bump-dnspython-requirement-to-2.2.1-a3d062a1e16cc8a9.yaml
@@ -0,0 +1,5 @@
+---
+upgrade:
+  - |
+    Designate has increased the minimum version of dnspython to 2.2.1 for the
+    antelope (2023.1) release to reflect support for python 3.10.
diff --git a/requirements.txt b/requirements.txt
index 4fb79d666..8fa602302 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -37,7 +37,7 @@ tenacity>=6.0.0 # Apache-2.0
 SQLAlchemy>=1.2.19 # MIT
 stevedore>=1.20.0 # Apache-2.0
 WebOb>=1.7.1 # MIT
-dnspython>=1.16.0  # http://www.dnspython.org/LICENSE
+dnspython>=2.2.1  # http://www.dnspython.org/LICENSE
 oslo.db>=8.3.0 # Apache-2.0
 oslo.i18n>=3.20.0 # Apache-2.0
 oslo.context>=4.0.0 # Apache-2.0