diff --git a/.zuul.yaml b/.zuul.yaml
index af6fa6e1e6..4c7f68d7dc 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -68,6 +68,16 @@
         nodes:
           - controller
 
+- nodeset:
+    name: devstack-single-node-debian-trixie
+    nodes:
+      - name: controller
+        label: debian-trixie-8GB
+    groups:
+      - name: tempest
+        nodes:
+          - controller
+
 - nodeset:
     name: devstack-single-node-debian-bookworm
     nodes:
@@ -383,6 +393,36 @@
         nodes:
           - compute1
 
+- nodeset:
+    name: devstack-two-node-debian-trixie
+    nodes:
+      - name: controller
+        label: debian-trixie-8GB
+      - name: compute1
+        label: debian-trixie-8GB
+    groups:
+      # Node where tests are executed and test results collected
+      - name: tempest
+        nodes:
+          - controller
+      # Nodes running the compute service
+      - name: compute
+        nodes:
+          - controller
+          - compute1
+      # Nodes that are not the controller
+      - name: subnode
+        nodes:
+          - compute1
+      # Switch node for multinode networking setup
+      - name: switch
+        nodes:
+          - controller
+      # Peer nodes for multinode networking setup
+      - name: peers
+        nodes:
+          - compute1
+
 - job:
     name: devstack-base
     parent: openstack-multinode-fips
@@ -807,6 +847,15 @@
     timeout: 9000
     voting: false
 
+- job:
+    name: devstack-platform-debian-trixie
+    parent: tempest-full-py3
+    description: Debian Trixie platform test
+    nodeset: devstack-single-node-debian-trixie
+    timeout: 9000
+    vars:
+      configure_swap_size: 4096
+
 - job:
     name: devstack-platform-debian-bookworm
     parent: tempest-full-py3
@@ -991,6 +1040,7 @@
         - devstack-platform-centos-10-stream
         - devstack-platform-centos-9-stream
         - devstack-platform-debian-bookworm
+        - devstack-platform-debian-trixie
         - devstack-platform-rocky-blue-onyx
         - devstack-platform-rocky-red-quartz
         - devstack-platform-ubuntu-noble-ovn-source
@@ -1022,6 +1072,7 @@
         - devstack
         - devstack-ipv6
         - devstack-platform-debian-bookworm
+        - devstack-platform-debian-trixie
         - devstack-platform-ubuntu-noble
         # NOTE(danms): Disabled due to instability, see comment in the job
         # definition above.
diff --git a/files/debs/general b/files/debs/general
index 364f3cc6e2..1e63e4f582 100644
--- a/files/debs/general
+++ b/files/debs/general
@@ -11,10 +11,8 @@ gettext  # used for compiling message catalogs
 git
 graphviz # needed for docs
 iputils-ping
-libapache2-mod-proxy-uwsgi
 libffi-dev # for pyOpenSSL
 libjpeg-dev # Pillow 3.0.0
-libpcre3-dev # for python-pcre
 libpq-dev  # psycopg2
 libssl-dev # for pyOpenSSL
 libsystemd-dev # for systemd-python
diff --git a/lib/apache b/lib/apache
index c49da711e1..b3379a7cde 100644
--- a/lib/apache
+++ b/lib/apache
@@ -82,7 +82,7 @@ function install_apache_uwsgi {
     fi
 
     if is_ubuntu; then
-        local pkg_list="uwsgi uwsgi-plugin-python3 libapache2-mod-proxy-uwsgi"
+        local pkg_list="uwsgi uwsgi-plugin-python3"
         install_package ${pkg_list}
     # NOTE(ianw) 2022-02-03 : Fedora 35 needs to skip this and fall
     # into the install-from-source because the upstream packages
diff --git a/lib/databases/mysql b/lib/databases/mysql
index 629014c1d8..a47580ca3d 100644
--- a/lib/databases/mysql
+++ b/lib/databases/mysql
@@ -20,7 +20,7 @@ if [[ -z "$MYSQL_SERVICE_NAME" ]]; then
     MYSQL_SERVICE_NAME=mysql
     if is_fedora && ! is_oraclelinux; then
         MYSQL_SERVICE_NAME=mariadb
-    elif [[ "$DISTRO" =~ bookworm|bullseye ]]; then
+    elif [[ "$DISTRO" =~ trixie|bookworm|bullseye ]]; then
         MYSQL_SERVICE_NAME=mariadb
     fi
 fi
@@ -107,7 +107,7 @@ function configure_database_mysql {
     # for Ubuntu 22.04+ because the authorization model change in
     # version 10.4 of mariadb. See
     # https://mariadb.org/authentication-in-mariadb-10-4/
-    if ! (is_ubuntu && [[ ! "$DISTRO" =~ bookworm|bullseye ]] && [ "$MYSQL_SERVICE_NAME" == "mariadb" ]); then
+    if ! (is_ubuntu && [[ ! "$DISTRO" =~ trixie|bookworm|bullseye ]] && [ "$MYSQL_SERVICE_NAME" == "mariadb" ]); then
         sudo mysqladmin -u root password $DATABASE_PASSWORD || true
     fi
 
@@ -119,6 +119,16 @@ function configure_database_mysql {
         local cmd_args="-uroot -p$DATABASE_PASSWORD -h$SERVICE_LOCAL_HOST "
     fi
 
+    # Workaround for mariadb > 11.6.2,
+    # see https://bugs.launchpad.net/nova/+bug/2116186/comments/3
+    min_db_ver="11.6.2"
+    db_version=$(sudo mysql ${cmd_args} -e "select version();" -sN | cut -d '-' -f 1)
+    max_db_ver=$(printf '%s\n' ${min_db_ver} ${db_version} | sort -V | tail -n 1)
+    if [[ "${min_db_ver}" != "${max_db_ver}" ]]; then
+        iniset -sudo $my_conf mysqld innodb_snapshot_isolation OFF
+        restart_service $MYSQL_SERVICE_NAME
+    fi
+
     # In mariadb e.g. on Ubuntu socket plugin is used for authentication
     # as root so it works only as sudo. To restore old "mysql like" behaviour,
     # we need to change auth plugin for root user
diff --git a/stack.sh b/stack.sh
index a7f6a5e903..5ef98eb7b7 100755
--- a/stack.sh
+++ b/stack.sh
@@ -1,6 +1,5 @@
 #!/usr/bin/env bash
 
-
 # ``stack.sh`` is an opinionated OpenStack developer installation.  It
 # installs and configures various combinations of **Cinder**, **Glance**,
 # **Horizon**, **Keystone**, **Nova**, **Neutron**, and **Swift**
@@ -230,7 +229,7 @@ write_devstack_version
 
 # Warn users who aren't on an explicitly supported distro, but allow them to
 # override check and attempt installation with ``FORCE=yes ./stack``
-SUPPORTED_DISTROS="bookworm|jammy|noble|rhel9|rhel10"
+SUPPORTED_DISTROS="trixie|bookworm|jammy|noble|rhel9|rhel10"
 
 if [[ ! ${DISTRO} =~ $SUPPORTED_DISTROS ]]; then
     echo "WARNING: this script has not been tested on $DISTRO"