diff --git a/openstack_dashboard/local/local_settings.py.example b/openstack_dashboard/local/local_settings.py.example
index ac54f6db0d..ade31c50a0 100644
--- a/openstack_dashboard/local/local_settings.py.example
+++ b/openstack_dashboard/local/local_settings.py.example
@@ -95,7 +95,7 @@ SECRET_KEY = secret_key.generate_or_read_from_file(
 # https://docs.djangoproject.com/en/1.11/topics/http/sessions/.
 #CACHES = {
 #    'default': {
-#        'BACKEND': 'django.core.cache.backends.memcached.MemcachedCache',
+#        'BACKEND': 'django.core.cache.backends.memcached.PyMemcacheCache',
 #        'LOCATION': '127.0.0.1:11211',
 #    },
 #}
diff --git a/openstack_dashboard/settings.py b/openstack_dashboard/settings.py
index 23d52a50b7..0f7724eff2 100644
--- a/openstack_dashboard/settings.py
+++ b/openstack_dashboard/settings.py
@@ -172,7 +172,7 @@ MESSAGE_STORAGE = 'django.contrib.messages.storage.fallback.FallbackStorage'
 SESSION_ENGINE = 'django.contrib.sessions.backends.cache'
 CACHES = {
     'default': {
-        'BACKEND': 'django.core.cache.backends.memcached.MemcachedCache',
+        'BACKEND': 'django.core.cache.backends.memcached.PyMemcacheCache',
         'LOCATION': '127.0.0.1:11211',
     },
 }
diff --git a/releasenotes/notes/bug-2039225-39b7060a7e4bff07.yaml b/releasenotes/notes/bug-2039225-39b7060a7e4bff07.yaml
new file mode 100644
index 0000000000..4fdecdea0e
--- /dev/null
+++ b/releasenotes/notes/bug-2039225-39b7060a7e4bff07.yaml
@@ -0,0 +1,8 @@
+---
+upgrade:
+  - |
+    Default cache backend has been changed from MemcachedCache backend to
+    PyMemcacheCache backend. MemcachedCache backend was deprecated in django
+    3.2 and was later removed in django 4.1. Note that the LOCATION option
+    needs to be updated in case memcached servers use IPv6, so that inet6
+    prefix is not included.
diff --git a/test-requirements.txt b/test-requirements.txt
index 77cf8727cf..803fa25faa 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -12,7 +12,7 @@ nodeenv>=0.9.4 # BSD
 pytest>=5.3.5 # MIT
 pytest-django>=3.8.0 # BSD (3 clause)
 pytest-html>=2.0.1 #MPL-2.0
-python-memcached>=1.59 # PSF
+pymemcache>=4.0.0  # Apache 2.0 License
 selenium>=2.50.1 # Apache-2.0
 testscenarios>=0.4 # Apache-2.0/BSD
 testtools>=2.2.0 # MIT