diff --git a/.zuul.yaml b/.zuul.yaml
index 0c4c3f02c8f2..155695c7eef2 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -369,8 +369,6 @@
         - devstack-plugin-ceph-tempest-py3:
             voting: false
             irrelevant-files: *dsvm-irrelevant-files
-        - neutron-grenade-multinode:
-            irrelevant-files: *dsvm-irrelevant-files
         - neutron-tempest-linuxbridge:
             irrelevant-files:
               # NOTE(mriedem): This job has its own irrelevant-files section
diff --git a/playbooks/legacy/nova-grenade-multinode/run.yaml b/playbooks/legacy/nova-grenade-multinode/run.yaml
index d77fc0b9f953..18f7c753ebcc 100644
--- a/playbooks/legacy/nova-grenade-multinode/run.yaml
+++ b/playbooks/legacy/nova-grenade-multinode/run.yaml
@@ -31,7 +31,13 @@
           export PYTHONUNBUFFERED=true
           export DEVSTACK_GATE_CONFIGDRIVE=0
           export DEVSTACK_GATE_NEUTRON=1
-          export DEVSTACK_GATE_TEMPEST_NOTESTS=1
+          # NOTE(mriedem): Run tempest smoke tests specific to compute on the
+          # new side of the grenade environment. The post-test hook script will
+          # run non-smoke migration tests in a local/block and shared/ceph
+          # setup. Note that grenade hard-codes "tox -esmoke" for tempest on
+          # the old side so the regex is not appied there.
+          export DEVSTACK_GATE_TEMPEST=1
+          export DEVSTACK_GATE_TEMPEST_REGEX="tempest\.(api\.compute|scenario)\..*smoke.*"
           export DEVSTACK_GATE_GRENADE=pullup
           export DEVSTACK_GATE_USE_PYTHON3=True
           # By default grenade runs only smoke tests so we need to set