diff --git a/swiftclient/client.py b/swiftclient/client.py
index e42ac700..b9f12aac 100644
--- a/swiftclient/client.py
+++ b/swiftclient/client.py
@@ -1821,7 +1821,9 @@ class Connection:
                     retried_auth = True
                 elif self.attempts > self.retries or err.http_status is None:
                     raise
-                elif err.http_status == 408:
+                elif err.http_status in (408, 499):
+                    # Server hit a timeout, so HTTP request/response framing
+                    # are likely in a bad state; trash the connection
                     self.http_conn = None
                 elif 500 <= err.http_status <= 599:
                     pass
diff --git a/test/unit/test_swiftclient.py b/test/unit/test_swiftclient.py
index ae3e76fd..55b4679a 100644
--- a/test/unit/test_swiftclient.py
+++ b/test/unit/test_swiftclient.py
@@ -2224,6 +2224,7 @@ class TestConnection(MockHttpTest):
         do_test(401, 2)
         # others will be tried until retry limits
         do_test(408, 6)
+        do_test(499, 6)
         do_test(500, 6)
         do_test(503, 6)