diff --git a/.gitignore b/.gitignore
index d67fb77..05a8740 100644
--- a/.gitignore
+++ b/.gitignore
@@ -35,4 +35,6 @@ AUTHORS
 ChangeLog
 
 # reno build
+RELEASENOTES.rst
 releasenotes/build
+releasenotes/notes/reno.cache
diff --git a/.zuul.yaml b/.zuul.yaml
index 35eecfd..a60d493 100644
--- a/.zuul.yaml
+++ b/.zuul.yaml
@@ -1,10 +1,8 @@
 - project:
     templates:
       - check-requirements
-      - lib-forward-testing
       - lib-forward-testing-python3
       - openstack-lower-constraints-jobs
-      - openstack-python-jobs
       - openstack-python3-ussuri-jobs
       - periodic-stable-jobs
       - publish-openstack-docs-pti
diff --git a/doc/requirements.txt b/doc/requirements.txt
index 3cf3164..701bdb1 100644
--- a/doc/requirements.txt
+++ b/doc/requirements.txt
@@ -3,5 +3,4 @@
 # process, which may cause wedges in the gate later.
 openstackdocstheme>=1.18.1 # Apache-2.0
 reno>=2.5.0 # Apache-2.0
-sphinx!=1.6.6,!=1.6.7,>=1.6.2,<2.0.0;python_version=='2.7' # BSD
-sphinx!=1.6.6,!=1.6.7,!=2.1.0,>=1.6.2;python_version>='3.4' # BSD
+sphinx>=2.0.0 # BSD
diff --git a/lower-constraints.txt b/lower-constraints.txt
index ea25162..3769f61 100644
--- a/lower-constraints.txt
+++ b/lower-constraints.txt
@@ -19,10 +19,9 @@ python-subunit==1.0.0
 pytz==2013.6
 PyYAML==3.12
 requests==2.14.2
-six==1.10.0
 smmap==0.9.0
 snowballstemmer==1.2.1
-Sphinx==1.6.5
+Sphinx==2.0.0
 sphinxcontrib-websupport==1.0.1
 stestr==2.0.0
 testtools==2.2.0
diff --git a/releasenotes/notes/drop-python2-support-3f0f717570cad8cb.yaml b/releasenotes/notes/drop-python2-support-3f0f717570cad8cb.yaml
new file mode 100644
index 0000000..3024edc
--- /dev/null
+++ b/releasenotes/notes/drop-python2-support-3f0f717570cad8cb.yaml
@@ -0,0 +1,4 @@
+---
+upgrade:
+  - |
+    Support for Python 2.7 is removed. Python 3.6 or greater is now required.
diff --git a/requirements.txt b/requirements.txt
index a072ac0..6de9f4e 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -3,4 +3,3 @@
 # process, which may cause wedges in the gate later.
 
 pbr!=2.1.0,>=2.0.0 # Apache-2.0
-six>=1.10.0 # MIT
diff --git a/setup.cfg b/setup.cfg
index f6db819..280f9f0 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -5,22 +5,19 @@ author = OpenStack
 author-email = openstack-discuss@lists.openstack.org
 summary = Manage dynamic plugins for Python applications
 home-page = https://docs.openstack.org/stevedore/latest/
+python-requires = >=3.6
 classifier =
     Development Status :: 5 - Production/Stable
     License :: OSI Approved :: Apache Software License
     Programming Language :: Python
-    Programming Language :: Python :: 2
-    Programming Language :: Python :: 2.7
     Programming Language :: Python :: 3
     Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
+    Programming Language :: Python :: 3 :: Only
+    Programming Language :: Python :: Implementation :: CPython
     Intended Audience :: Developers
     Environment :: Console
 
-[global]
-setup-hooks =
-    pbr.hooks.setup_hook
-
 [files]
 packages =
     stevedore
@@ -30,15 +27,8 @@ stevedore.example.formatter =
     simple = stevedore.example.simple:Simple
     field = stevedore.example2.fields:FieldList
     plain = stevedore.example.simple:Simple
-
 stevedore.test.extension =
     t1 = stevedore.tests.test_extension:FauxExtension
     t2 = stevedore.tests.test_extension:FauxExtension
     e1 = stevedore.tests.test_extension:BrokenExtension
     e2 = stevedore.tests.notfound:UnimportableExtension
-
-[pbr]
-warnerrors = True
-
-[wheel]
-universal = true
diff --git a/setup.py b/setup.py
index 566d844..f63cc23 100644
--- a/setup.py
+++ b/setup.py
@@ -16,14 +16,6 @@
 # THIS FILE IS MANAGED BY THE GLOBAL REQUIREMENTS REPO - DO NOT EDIT
 import setuptools
 
-# In python < 2.7.4, a lazy loading of package `pbr` will break
-# setuptools if some other modules registered functions in `atexit`.
-# solution from: http://bugs.python.org/issue15881#msg170215
-try:
-    import multiprocessing  # noqa
-except ImportError:
-    pass
-
 setuptools.setup(
     setup_requires=['pbr>=2.0.0'],
     pbr=True)
diff --git a/stevedore/__init__.py b/stevedore/__init__.py
index a471f31..fdf37a9 100644
--- a/stevedore/__init__.py
+++ b/stevedore/__init__.py
@@ -21,4 +21,3 @@ import logging
 LOG = logging.getLogger('stevedore')
 
 LOG.addHandler(logging.NullHandler())
-
diff --git a/stevedore/example/base.py b/stevedore/example/base.py
index ec95424..08f8a5c 100644
--- a/stevedore/example/base.py
+++ b/stevedore/example/base.py
@@ -1,10 +1,7 @@
 import abc
 
-import six
 
-
-@six.add_metaclass(abc.ABCMeta)
-class FormatterBase(object):
+class FormatterBase(metaclass=abc.ABCMeta):
     """Base class for example plugin used in the tutorial.
     """
 
diff --git a/stevedore/sphinxext.py b/stevedore/sphinxext.py
index 8ca88bb..bdfa023 100644
--- a/stevedore/sphinxext.py
+++ b/stevedore/sphinxext.py
@@ -10,8 +10,6 @@
 #    License for the specific language governing permissions and limitations
 #    under the License.
 
-from __future__ import unicode_literals
-
 import inspect
 
 from docutils import nodes
diff --git a/test-requirements.txt b/test-requirements.txt
index bbe4106..11808ac 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -6,7 +6,4 @@ mock>=2.0.0 # BSD
 coverage!=4.4,>=4.0 # Apache-2.0
 stestr>=2.0.0 # Apache-2.0
 # sphinx is needed for testing the sphinxext module
-sphinx!=1.6.6,!=1.6.7,>=1.6.5,<2.0.0;python_version=='2.7' # BSD
-sphinx!=1.6.6,!=1.6.7,>=1.6.5;python_version>='3.4' # BSD
-# Bandit security code scanner
-bandit>=1.1.0,<1.6.0 # Apache-2.0
+sphinx>=2.0.0 # BSD
diff --git a/tox.ini b/tox.ini
index b1f4ca8..72dd206 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,18 +1,17 @@
 [tox]
-minversion = 2.0
-envlist = py27,py37,pep8,docs
+minversion = 3.2
+envlist = py37,pep8,docs
+ignore_basepython_conflict = true
 
 [testenv]
-install_command = pip install {opts} {packages}
+basepython = python3
 deps =
   -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master}
   -r{toxinidir}/test-requirements.txt
   -r{toxinidir}/requirements.txt
-distribute = False
 commands = stestr run {posargs}
 
 [testenv:venv]
-basepython = python3
 deps =
   -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master}
   -r{toxinidir}/test-requirements.txt
@@ -21,35 +20,31 @@ deps =
 commands = {posargs}
 
 [testenv:pep8]
-basepython = python3
 deps =
-  -r{toxinidir}/test-requirements.txt
-  flake8
+  flake8 # MIT
+  bandit>=1.1.0,<1.6.0 # Apache-2.0
 ignore = E251
 commands =
   flake8 stevedore setup.py
   # Run security linter
   bandit -r stevedore -x tests -n5
 
-[testenv:docs]
-basepython = python3
-deps = -r{toxinidir}/doc/requirements.txt
-commands = sphinx-build -W -b html doc/source doc/build/html
-
 [flake8]
 ignore = E251
 show-source = True
 exclude=.venv,.git,.tox,dist,*lib/python*,*egg,build
 
-[testenv:releasenotes]
-basepython = python3
+[testenv:docs]
 deps =
   -c{env:UPPER_CONSTRAINTS_FILE:https://releases.openstack.org/constraints/upper/master}
   -r{toxinidir}/doc/requirements.txt
-commands = sphinx-build -a -E -W -d releasenotes/build/doctrees -b html releasenotes/source releasenotes/build/html
+commands = sphinx-build -a -E -W doc/source doc/build/html
+
+[testenv:releasenotes]
+deps = {[testenv:docs]deps}
+commands = sphinx-build -a -E -W releasenotes/source releasenotes/build/html
 
 [testenv:bindep]
-basepython = python3
 # Do not install any requirements. We want this to be fast and work even if
 # system dependencies are missing, since it's used to tell you what system
 # dependencies are missing! This also means that bindep must be installed
@@ -61,7 +56,6 @@ commands = bindep test
 usedevelop = False
 
 [testenv:lower-constraints]
-basepython = python3
 deps =
   -c{toxinidir}/lower-constraints.txt
   -r{toxinidir}/test-requirements.txt