diff --git a/.stestr.conf b/.stestr.conf
new file mode 100644
index 0000000..ea359ca
--- /dev/null
+++ b/.stestr.conf
@@ -0,0 +1,3 @@
+[DEFAULT]
+test_path=./tests
+top_dir=./
diff --git a/test-requirements.txt b/test-requirements.txt
index e0b5dbc..cc29ece 100644
--- a/test-requirements.txt
+++ b/test-requirements.txt
@@ -2,7 +2,7 @@ transaction
 pecan
 sphinx>=3.0.0 # BSD
 Flask
-flask-restful
-nose
-coverage!=4.4,>=4.0 # Apache-2.0
-webtest
+Flask-RESTful # BSD
+pytest # MIT
+pytest-cov # MIT
+WebTest # MIT
diff --git a/tox.ini b/tox.ini
index 03023cc..8343343 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,29 +1,23 @@
 [tox]
-minversion = 3.1
-envlist = py36,py37,py38,py39,pypy,coverage,pep8
-ignore_basepython_conflict = true
+minversion = 4.4
+envlist = py3,coverage,pep8
 
 [testenv]
-basepython = python3
-setenv =
-  COVERAGE_FILE=.coverage.{envname}
 deps =
   -r test-requirements.txt
 commands =
-  {envbindir}/coverage run {envbindir}/nosetests --nologcapture --with-xunit --xunit-file nosetests-{envname}.xml wsme/tests tests/pecantest tests/test_sphinxext.py tests/test_flask.py --verbose {posargs}
-  {envbindir}/coverage report --show-missing --include="wsme/*.py","wsme/rest/*.py","wsmeext/*.py" --omit "wsme/tests/*"
+  pytest wsme/tests tests/pecantest tests/test_sphinxext.py tests/test_flask.py
 
 [testenv:coverage]
-setenv =
-  COVERAGE_FILE=.coverage
 commands =
-  {envbindir}/coverage erase
-  {envbindir}/coverage combine
-  {envbindir}/coverage xml --include="wsme/*.py","wsme/rest/*.py","wsmeext/*.py" --omit "wsme/tests/*"
-  {envbindir}/coverage report --show-missing --include="wsme/*.py","wsme/rest/*.py","wsmeext/*.py" --omit "wsme/tests/*"
+  coverage erase
+  pytest --cov=wsme --cov=wsme_ext wsme/tests tests/pecantest tests/test_sphinxext.py tests/test_flask.py
+  coverage combine
+  coverage xml --include="wsme/*.py","wsme/rest/*.py","wsmeext/*.py" --omit "wsme/tests/*"
+  coverage report --show-missing --include="wsme/*.py","wsme/rest/*.py","wsmeext/*.py" --omit "wsme/tests/*"
 
 [testenv:docs]
-whitelist_externals =
+allowlist_externals =
   rm
 deps =
   -r doc/requirements.txt